2013-07-10

Rate of aging may be determined in the womb and linked to birthweight, study reveals

Rate of aging may be determined in the womb and linked to birthweight, study reveals

July 9, 2013 — Scientists have found that key metabolites in blood -- chemical 'fingerprints' left behind as a result of early molecular changes before birth or in infancy -- could provide clues to a person's long-term overall health and rate of aging in later life.


Share This:





Published today in the International Journal of Epidemiology, the international study of twins led by King's College London highlights how a technique called metabolomic profiling has revealed a collection of 22 metabolites linked to aging. One of these, linked to aging traits such as lung function and bone mineral density, is also strongly associated with birthweight -- a well-known developmental determinant of healthy aging.

This finding suggests that levels of this novel metabolite, which may be determined in the womb and affected by nutrition during development, could reflect accelerated aging in later adult life. Scientists say the findings show it is possible that these markers of aging can be identified with simple blood tests in the future, which may provide further clues to the aging process and could pave the way for development of therapies to treat age-related conditions.

Professor Tim Spector, Head of the Department of Twin Research at King's College London, said: 'Scientists have known for a long time that a person's weight at the time of birth is an important determinant of health in middle and old age, and that people with low birth weight are more susceptible to age related diseases. So far the molecular mechanisms that link low birthweight to health or disease in old age had remained elusive, but this discovery has revealed one of the molecular pathways involved.'

Funded by the European Commission, Researchers from the Department of Twin Research at King's carried out metabolomic profiling -- the study of metabolites that specific cellular processes or changes leave behind in the blood. Analysing blood samples donated by over 6,000 twins, they identified 22 metabolites directly linked to chronological age -- the concentrations of the metabolites were higher in older people than in younger people.

One particular metabolite -- C-glyTrp -- is associated with a range of age-related traits such as lung function, bone mineral density, cholesterol and blood pressure. Its role in aging is completely novel. Crucially, researchers found it was also associated with lower weight at birth when they compared the birth weights of identical twins.

To explore the link between birth weight and the metabolite, the researchers showed via genetic tests that the gene influencing the levels could be modified epigenetically (whereby genes are switched on or off by chemical switches triggered by the person's environment or lifestyle). These epigenetic changes may then influence metabolism during a person's lifetime, which in turn influences their risk of age-related diseases.

Ana Valdes, lead researcher from King's, said: 'Human aging is a process influenced by genetic, lifestyle and environmental factors, but genes only explain a part of the story. Molecular changes that influence how we age over time are triggered by epigenetic changes. This study has for the first time used analysis of blood and epigenetic changes to identify a novel metabolite that has a link to birthweight and rate of aging.

'This unique metabolite, which is related to age and age related diseases, was different in genetically identical twins that had very different weight at birth. This shows us that birth weight affects a molecular mechanism that alters this metabolite. This may help us understand how lower nutrition in the womb alters molecular pathways that result in faster aging and a higher risk of age-related diseases fifty years later.

'Understanding the molecular pathways involved in the aging process could ultimately pave the way for future therapies to treat age-related conditions. As these 22 metabolites linked to aging are detectable in the blood, we can now predict actual age from a blood sample pretty accurately and in the future this can be refined to potentially identify future rapid biological aging in individuals.'



Welcome to SUV System Ltd!

SUV System Ltd is ISO 90012008 Certified electronics distributor with 10 years of experiences.

We have built up long term business relationship with about many companies which are stockers and authorized agents. we have a steady and reliable supply to meet customer's demands to the greatest extent .Confidently, we are able to lower your cost and support your business with our years of professional service.

SUV System Ltd is Electronic Components Distributor Supplies,Find Quality Electronic Components Supplies Products IC(Integrated Circuits),Connectors,Capacitor,Resistors,Diodes,Transistors,LED at Suvsystem.com. Sourcing Other Energy, Environment, Excess Inventory Products from Manufacturers and Suppliers at Suvsystem.com

Electronic Components distributor:http://www.suvsystem.com

Connectors Distributor:http://www.suvsystem.com/l/Connectors-1.html

IC Distributor:http://www.suvsystem.com/l/IC(Integrated-Circuits)-1.html

LED Distributor:http://www.suvsystem.com/l/LED-1.html

Capacitor Distributor:http://www.suvsystem.com/l/Capacitor-1.html

Transistor Distributor:http://www.suvsystem.com/l/Transistors-1.html

Resistor Distributor:http://www.suvsystem.com/l/Resistors-1.html

Diode Distributor:http://www.suvsystem.com/l/Diodes-1.html

SUV System Ltd insists on the managing faith ofsincereness,speciality,foresight, win-win,so we build up stable-relationship customers located all over the world, including the States, Europe, Argentina, UAE, Malaysia, Australia,and India etc

we are focus on the following fields,and hope we can help you.


ELPIDA IC Voltage Regulators Transistors MURATA IC IC(Integrated Circuits) PANASONIC TOSHIBA Diodes Fleld Effect Transistors IR Diodes Rectifier Diodes NXP Transistors Bipolar Transistors DIODES Transistors Thick Film Resistors Industrial IC AD IC VISHAY IC Chip Fuses Vishay resistors Chip Inductors Dialight LED chip Filter saws IR transistor Transistors Freescale Renesas parts IC SANYO IC Freescale Semiconductor Civil IC ST Diodes Current Sensors Resistors ST Transistors components INTERSIL IC ROHM Resistors Thin Film Resistors Texas Instruments(TI) IC Atmel IC Multi-units Transistors Low Ohmic Resistors Resistors NEC Transistors
http://www.suvsystem.com/a/3573.aspx

No comments:

Post a Comment